Plant viral vectors: an strategy for transient expression of recombinant proteins in plants
DOI:
https://doi.org/10.53660/CONJ-633-515Palavras-chave:
Agrobacterium, Agroinfiltration, Viral vectors, Recombinant proteinsResumo
Plants have been studied as bioreactors for over 30 years. Their advantages over other expression methods arouse interest in this heterologous protein expression system. Over the years, several methods of plant transformation were developed, and among them, the transient expression system - that occurs temporarily and without integration into the host genome. The use of viral vectors for this type of expression stands out, and the viral genome can be “full-length” or “deconstructed”. Some genome modifications in the “deconstructed” form help searching for efficient protein expression, and several types of viruses are studied to develop these vectors. This review reports different types of viral vectors, especially those particularly suitable for the development of effective vectors of fast and high yield recombinant protein production, based on Tobamoviruses, Potexviruses, Geminiviruses and Comoviruses.
Downloads
Referências
ASURMENDI, S. et al. Coat protein regulates formation of replication complexes during tobacco mosaic virus infection. Proceedings of the National Academy of Sciences, v. 101, n. 5, p. 1415–1420, 2004.
AZHAKANANDAM, K. et al. Amplicon-plus targeting technology (APTT) for rapid production of a highly unstable vaccine protein in tobacco plants. Plant Molecular Biology, v. 63, n. 3, p. 393–404, 2007.
BAMOGO, P. K. A. et al. Virus-based pharmaceutical production in plants: an opportunity to reduce health problems in Africa. Virology Journal, v. 16, n. 1, 2019.
BOUTON, C. et al. Foxtail mosaic virus: A Viral Vector for Protein Expression in Cereals. Plant Physiology, v. 177, n. 4, p. 1352–1367, 2018.
CARLSSON, M. L. R. et al. Plant based production of myoglobin - a novel source of the muscle heme-protein. Scientific Reports, v. 10, n. 1, 2020.
CHAPMAN, S.; KAVANAGH, T.; BAULCOMBE, D. Potato virus X as a vector for gene expression in plants. The Plant Journal, v. 2, n. 4, p. 549–557, 1992.
CHEN, M.-H. et al. Interaction between the tobacco mosaic virus movement protein and host cell pectin methylesterases is required for viral cell-to-cell movement. The EMBO Journal, v. 19, n. 5, p. 913–920, 2000.
CHEN, Q. et al. Geminiviral vectors based on bean yellow dwarf virus for production of vaccine antigens and monoclonal antibodies in plants. Human Vaccines, v. 7, n. 3, p. 331–338, 2011.
CHEN, T.-H. et al. Induction of protective immunity in chickens immunized with plant-made chimeric Bamboo mosaic virus particles expressing very virulent Infectious bursal disease virus antigen. Virus Research, v. 166, n. 1-2, p. 109–115, 2012.
CHEN, T.-H. et al. Production of Japanese Encephalitis Virus Antigens in Plants Using Bamboo Mosaic Virus-Based Vector. Frontiers in Microbiology, v. 8, 2017.
DANIELL, H. et al. Plant-made vaccine antigens and biopharmaceuticals. Trends in Plant Science, v. 14, n. 12, p. 669–679, 2009.
DEMURTAS, O. C. et al. Antigen Production in Plant to Tackle Infectious Diseases Flare Up: The Case of SARS. Frontiers in Plant Science, v. 7, 2016.
DICKMEIS, C.; FISCHER, R.; COMMANDEUR, U. Potato virus X-based expression vectors are stabilized for long-term production of proteins and larger inserts. Biotechnology Journal, v. 9, n. 11, p. 1369–1379, 2014.
D’AOUST, M.-A. et al. The production of hemagglutinin-based virus-like particles in plants: a rapid, efficient and safe response to pandemic influenza. Plant Biotechnology Journal, v. 8, n. 5, p. 607–619, 2010.
FAHAD, S. et al. Recent developments in therapeutic protein expression technologies in plants. Biotechnology Letters, v. 37, n. 2, p. 265–279, 2014.
GIRITCH, A. et al. Rapid high-yield expression of full-size IgG antibodies in plants coinfected with noncompeting viral vectors. Proceedings of the National Academy of Sciences, v. 103, n. 40, p. 14701–14706, 2006.
GLEBA, Y.; KLIMYUK, V.; MARILLONNET, S. Magnifection?a new platform for expressing recombinant vaccines in plants. Vaccine, v. 23, n. 17-18, p. 2042–2048, 2005.
GLEBA, Y.; KLIMYUK, V.; MARILLONNET, S. Viral vectors for the expression of proteins in plants. Current Opinion in Biotechnology, v. 18, n. 2, p. 134–141, 2007.
HEFFERON, K. Plant Virus Expression Vector Development: New Perspectives. BioMed Research International, v. 2014, p. 1–6, 2014.
HEFFERON, K. Plant Virus Expression Vectors: A Powerhouse for Global Health. Biomedicines, v. 5, n. 4, p. 44, 2017.
HEFFERON, K. L. The role of plant expression platforms in biopharmaceutical development: possibilities for the future. Expert Review of Vaccines, v. 18, n. 12, p. 1301–1308, 2019.
HILF, M. E.; DAWSON, W. O. The Tobamovirus Capsid Protein Functions as a Host-Specific Determinant of Long-Distance Movement. Virology, v. 193, n. 1, p. 106–114, 1993.
HURTADO, J. et al. In vitro and in vivo efficacy of anti‐chikungunya virus monoclonal antibodies produced in wild‐type and glycoengineered Nicotiana benthamiana plants. Plant Biotechnology Journal, v. 18, n. 1, p. 266–273, 2019.
IBRAHIM, A.; ODON, V.; KORMELINK, R. Plant Viruses in Plant Molecular Pharming: Toward the Use of Enveloped Viruses. Frontiers in Plant Science, v. 10, 2019.
KOMAROVA, T. V. et al. Transient expression systems for plant-derived biopharmaceuticals. Expert Review of Vaccines, v. 9, n. 8, p. 859–876, 2010.
LEE, W.-S.; HAMMOND-KOSACK, K. E.; KANYUKA, K. Barley Stripe Mosaic Virus-Mediated Tools for Investigating Gene Function in Cereal Plants and Their Pathogens: Virus-Induced Gene Silencing, Host-Mediated Gene Silencing, and Virus-Mediated Overexpression of Heterologous Protein. Plant Physiology, v. 160, n. 2, p. 582–590, 2012.
LINDBO, J. A. High-efficiency protein expression in plants from agroinfection-compatible Tobacco mosaic virus expression vectors. BMC Biotechnology, v. 7, n. 1, p. 52, 2007.
LINDBO, J. A. TRBO: A High-Efficiency Tobacco Mosaic Virus RNA-Based Overexpression Vector. Plant Physiology, v. 145, n. 4, p. 1232–1240, 2007.
LINDSAY, B. J. et al. Morphological characterization of a plant-made virus-like particle vaccine bearing influenza virus hemagglutinins by electron microscopy. Vaccine, v. 36, n. 16, p. 2147–2154, 2018.
LIU, P.-F. et al. Leaf-Encapsulated Vaccines: Agroinfiltration and Transient Expression of the AntigenStaphylococcal EndotoxinB in Radish Leaves. Journal of Immunology Research, v. 2018, p. 1–9, 2018.
LIU, Z.; KEARNEY, C. M. An efficient Foxtail mosaic virus vector system with reduced environmental risk. BMC Biotechnology, v. 10, n. 1, 2010.
LIU, Z.; KEARNEY, C. M. A tobamovirus expression vector for agroinfection of legumes and Nicotiana. Journal of Biotechnology, v. 147, n. 3-4, p. 151–159, 2010.
MARDANOVA, E. S. et al. Efficient Transient Expression of Recombinant Proteins in Plants by the Novel pEff Vector Based on the Genome of Potato Virus X. Frontiers in Plant Science, v. 8, 2017.
MARDANOVA, E. S. et al. High immunogenicity of plant-produced candidate influenza vaccine based on the M2e peptide fused to flagellin. Bioengineered, v. 7, n. 1, p. 28–32, 2016.
MATSUDA, R. et al. Effect of temperature post viral vector inoculation on the amount of hemagglutinin transiently expressed in Nicotiana benthamiana leaves. Journal of Bioscience and Bioengineering, v. 124, n. 3, p. 346–350, 2017.
MCCORMICK, A. A. et al. Plant-produced idiotype vaccines for the treatment of non-Hodgkin's lymphoma: Safety and immunogenicity in a phase I clinical study. Proceedings of the National Academy of Sciences, v. 105, n. 29, p. 10131–10136, 2008.
MESHCHERIAKOVA, Y. A.; SAXENA, P.; LOMONOSSOFF, G. P. Fine‐tuning levels of heterologous gene expression in plants by orthogonal variation of the untranslated regions of a nonreplicating transient expression system. Plant Biotechnology Journal, v. 12, n. 6, p. 718–727, 2014.
PATIL, B. L.; FAUQUET, C. M. Light intensity and temperature affect systemic spread of silencing signal in transient agroinfiltration studies. Molecular Plant Pathology, v. 16, n. 5, p. 484–494, 2014.
PEYRET, H.; LOMONOSSOFF, G. P. When plant virology metAgrobacterium: the rise of the deconstructed clones. Plant Biotechnology Journal, v. 13, n. 8, p. 1121–1135, 2015.
RUIZ, V. et al. Minimally processed crude leaf extracts of Nicotiana benthamiana containing recombinant foot and mouth disease virus-like particles are immunogenic in mice. Biotechnology Reports, v. 20, 2018.
SAINSBURY, F.; CAÑIZARES, M. C.; LOMONOSSOFF, G. P. Cowpea mosaicVirus: The Plant Virus–Based Biotechnology Workhorse. Annual Review of Phytopathology, v. 48, n. 1, p. 437–455, 2010.
SAINSBURY, F.; LOMONOSSOFF, G. P. Extremely High-Level and Rapid Transient Protein Production in Plants without the Use of Viral Replication. Plant Physiology, v. 148, n. 3, p. 1212–1218, 2008.
SAINSBURY, F. Innovation in plant-based transient protein expression for infectious disease prevention and preparedness. Current Opinion in Biotechnology, v. 61, p. 110–115, 2020.
SAINSBURY, F.; THUENEMANN, E. C.; LOMONOSSOFF, G. P. pEAQ: versatile expression vectors for easy and quick transient expression of heterologous proteins in plants. Plant Biotechnology Journal, v. 7, n. 7, p. 682–693, 2009.
SALAZAR-GONZÁLEZ, J. A.; BAÑUELOS-HERNÁNDEZ, B.; ROSALES-MENDOZA, S. Current status of viral expression systems in plants and perspectives for oral vaccines development. Plant Molecular Biology, v. 87, n. 3, p. 203–217, 2015.
SHOJI, Y. et al. A plant-produced H1N1 trimeric hemagglutinin protects mice from a lethal influenza virus challenge. Human Vaccines & Immunotherapeutics, v. 9, n. 3, p. 553–560, 2013.
TUSÉ, D. Safety of plant-made pharmaceuticals: Product development and regulatory considerations based on case studies of two autologous human cancer vaccines. Human Vaccines, v. 7, n. 3, p. 322–330, 2011.
WANG, Y. et al. Development of new potato virus X-based vectors for gene over-expression and gene silencing assay. Virus Research, v. 191, p. 62–69, 2014.
YANG, C.-D. et al. Induction of protective immunity in swine by recombinant bamboo mosaic virus expressing foot-and-mouth disease virus epitopes. BMC Biotechnology, v. 7, n. 1, p. 62, 2007.
YANG, M. et al. Virus-like particles that display Zika virus envelope protein domain III induce potent neutralizing immune responses in mice. Scientific Reports, v. 7, n. 1, 2017.
YUSIBOV, V. et al. Hybrid Viral Vectors for Vaccine and Antibody Production in Plants. Current Pharmaceutical Design, v. 19, n. 31, p. 5574–5586, 2013.
ZAHIN, M. et al. Scalable Production of HPV16 L1 Protein and VLPs from Tobacco Leaves. Plos One, v. 11, n. 8, 2016.
Downloads
Publicado
Como Citar
Edição
Seção
Licença
Copyright (c) 2022 Conjecturas
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
